Sains Malaysiana 53(2)(2024): 369-381

http://doi.org/10.17576/jsm-2024-5302-11

Anti-Angiogenic Effect of Polygonum Species: A Comprehensive Review of Literature

(Kesan Anti-Angiogenik Spesies Polygonum: Kajian Komprehensif Kepustakaan)

NAJLA’ SHAKIRAH AB HALIM¹, SHERIL JUNE ANKASHA¹, ASLAH NABILAH ABDULL SUKOR¹, NUR NAJMI MOHAMAD ANUAR², NORHAZLINA ABDUL WAHAB¹, SHAHIDEE ZAINAL ABIDIN³, AZIZAH UGUSMAN¹ & ADILA A HAMID^1,*

¹Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia

²Programme of Biomedical Science, Centre for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

³Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21300 Kuala Terengganu, Terengganu, Malaysia

Received: 13 September 2023/Accepted: 6 February 2024

Abstract

Angiogenesis is a physiological, tightly regulated process which is characterized by the development of new blood vessels. Compounds with the potential to control angiogenesis would be highly valuable as therapeutics, as an imbalance in angiogenesis may lead to several pathological disorders, including cancer, retinopathy, and arthritis. In this study, the anti-angiogenic effect of Polygonum sp. has been comprehensively reviewed and this plant also has been known to possess other medicinal benefits such as antioxidative, anti-inflammatory, anti-proliferative, and anti-tumor agents. Hence, this study systematically identified the evidence reporting the anti-angiogenic effects of Polygonum sp. Four electronic databases, namely PubMed, Ovid MEDLINE, Scopus and Web of Science were searched for relevant articles. Based on the pre-set eligibility criteria, 50 relevant articles were identified, and ten qualified articles were selected and reviewed. It was demonstrated that four namely P. cuspidatum, P. barbatum, P. hydropiper, and P. perfoliatum showed anti-angiogenic activities mainly through inhibition of the vascular endothelial growth factor-signaling pathways. Therefore, these species Polygonum have the potential to be developed as natural anti-angiogenic agents for prevention and treatment of various diseases related to pathological angiogenesis.

Keywords: Angiogenesis; anti-angiogenesis; Polygonum genus; vascular endothelial growth factor

Abstrak

Angiogenesis adalah proses fisiologi yang dikawal ketat yang dicirikan oleh perkembangan saluran darah baharu. Sebatian yang berpotensi untuk mengawal angiogenesis akan sangat berharga sebagai terapeutik, kerana ketidakseimbangan dalam angiogenesis boleh membawa kepada beberapa gangguan patologi, termasuk kanser, retinopati dan arthritis. Dalam kajian ini, kesan anti-angiogenik spesies Polygonum telah dikaji secara menyeluruh dan tumbuhan ini juga telah diketahui mempunyai manfaat perubatan lain seperti antioksidan, anti-radang, agen anti-proliferatif dan anti-tumor. Walau bagaimanapun, kesan anti-angiogenik Polygonum sp. masih belum diulas. Oleh itu, kajian ini dilakukan secara sistematik untuk mengenal pasti bukti yang melaporkan kesan anti-angiogenik oleh Polygonum sp. Empat pangkalan data elektronik, iaitu PubMed, Ovid MEDLINE, Scopus dan Web of Science digunakan bagi pencarian artikel yang berkaitan. Berdasarkan kriteria relevan yang telah ditetapkan, terdapat 50 artikel yang berkaitan telah dikenal pasti dan hanya sepuluh artikel yang layak telah dipilih dan diulas. Hasil kajian menunjukkan bahawa terdapat empat iaitu P. cuspidatum, P. barbatum, P. hidropiper dan P. perfoliatum menunjukkan aktiviti anti-angiogenik terutamanya melalui perencatan laluan isyarat faktor pertumbuhan endotelium vaskular. Oleh itu, spesies Polygonum sp. mempunyai potensi untuk dibangunkan sebagai agen anti-angiogenik semula jadi dalam pencegahan dan rawatan pelbagai penyakit yang berkaitan dengan patologi angiogenesis.

Kata kunci: Angiogenesis; anti-angiogenesis; faktor pertumbuhan endotelium vaskular; genus Polygonum

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*Corresponding author; email: adilahamid@ppukm.ukm.edu.my